Once you’re ready to transcend, you have nine options for spending your Ancient souls. Each of the Outsiders – Xyliqil, Chor’gorloth, Phandoryss, Borb, Ponyboy, K’Ariqua, Rhageist, Sen-Akhan, and Orphalas – offer a unique enhancement that will help boost your progression. When leveled correctly, they will work together to boost you farther and farther into Clicker Heroes each time you transcend. Which ones you level will depend largely on what stage of the game you’re on.
TL;DR: use this Outsider Calculator.
This guide has been updated for version 1.0e10 of Clicker Heroes.